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Yes, Vitamin D can be a magic bullet - Grant March 2020

Letter to the Editor: Yes, vitamin D can be a magic bullet

Clinical Nutrition VOLUME 39, ISSUE 5, P1627,
https://doi.org/10.1016Zj.dnu.2020.03.023. https://doi.org/10.1016Zj.dnu.2020.03.021

Dear Editor:
Reijven and Soeters [1] recently reviewed evidence from obser­vational studies and RCTs on vitamin D and various health out­comes and concluded: “The high incidence of low vit D levels in disease related inflammatory states is predominantly based on reversed causality. Inflammation causes a decrease in total plasma Vit D due to a decrease of its binding protein, but active Vit D does not change. In practice the assessment of Vit D status is especially indi­cated in patients with symptoms of malabsorption, renal failure, he­patic failure, patients with low bone mineral density, patients prone to malnutrition and patients who lack sun exposure."

Evidently these authors are not considering mechanistic evi­dence. One review notes, “The bone-centric guidelines recommend a target 25(OH)D concentration of 20 ng/mL (50 nmol/L), and age- dependent daily vitamin D doses of400-800IU. The guidelines focused on pleiotropic effects of vitamin D recommend a target 25(OH)D con­centration of 30 ng/mL (75 nmol/L), and age-, body weight-, disease- status, and ethnicity dependent vitamin D doses ranging between 400 and 2000IU/day." [2]

Regarding inflammatory disorders, meta-analysis of 28 studies showed that supplementation reduced serum hs-CRP by -0.20 ± 0.07 (95% Cl -0.34 to -0.06; p = 0.006) ng/mL [3], and vitamin D suppresses pro-inflammatory and increases anti­inflammatory cytokine secretion [4].
RCT health outcomes depend on raising deficient circulating 25(OH)D concentrations to levels adequate to allow target tissue activation rather than on the dose given or on the tightly regulated circulating calcitriol levels which do not reflect deficiency. Vitamin D RCTs should be based on baseline and achieved circulating 25(OH)D concentrations since Western populations commonly include many non-deficient participants, reducing or abolishing the apparent benefits of supplementation. Significant benefits are commonly seen in deficient study subgroups as recently reported in two major recent RCTs, where cancer and type 2 diabetes melli­tus development in pre-diabetes fell in subjects with deficiency or with low BMIs [5], as also reported in populations where deficiency is common.

Evidence for health benefits of better vitamin D status also comes from ecological studies where geographical variation of risk follows solar UVB doses, and health risks rise following low so­lar winter UVB and fall following high-summer sunshine; from Mendelian randomization demonstrations of health risk variation with gene variants relevant to vitamin-D3 production and activation, as supported by the many mechanistic benefits of acti­vated hormonal vitamin D. Overall, the available evidence is compelling for increasing numbers of beneficial health outcomes with correction of deficiency [e.g. acute upper respiratory tract in­fections, cancer, insulin resistance, type 2 diabetes mellitus and many pregnancy and birth outcomes]. Furthermore, the authors would need a better hypothesis for the evolution of variations in human skin pigmentation than a balance between vitamin D pro­duction and protection against solar tissue damage if their conten­tion were correct.
 Download the PDF from Sci-Hub via VitaminDWiki

References
  1. Reijven PLM, Soeters PB. Vitamin D: a magic bullet or a myth? Clin Nutr 2020 Jan 10. https://doi.org/10.1016/j.clnu.2019.12.028. pii: S0261-5614(20)30004-2. [Epub ahead of print].
  2. Pludowski P, Holick MF, Grant WB, KonstantynowiczJ, Mascarenhas MR, Haq A, et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol 2018;175:125-35.
  3. Mirhosseini N, Vatanparast H, Kimball SM. The association between serum 25(OH)D status and blood pressure in participants of a community-based pro­gram taking vitamin D supplements. Nutrients 2017;9:E1244.
  4. Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on im­mune function: lessons learned from genome-wide analysis. Front Physiol 2014;5:151.
  5. Grant WB, Boucher BJ. Why secondary analyses in vitamin D clinical trials are important and how to improve vitamin D clinical trial outcome analyses-A comment on "Extra-Skeletal effects of vitamin D. Nutrients 2019;11:E2182.

William B. Grant* Sunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA, 94164-1603, USA
Barbara J. Boucher The Blizard Institute Barts, The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

240+ targets of the magic bullet

50+ VitaminDWiki pages with GRANT in the title

This list is automatically updated

Items found: 56
Title Modified
23 Cancers in the US are associated with low UVB - Grant April 2024 17 May, 2024
Vitamin D: Viral infections, Infectious diseases, EBV and MS, Virus and Cancers – Grant March 2024 03 Mar, 2024
Top Vitamin D papers - Grant Jan 2020 03 Mar, 2024
Top 25 Vitamin D papers in 2020 - Grant 03 Mar, 2024
Increase life expectancy by 2 years if double Vitamin D levels – Grant July 2011 22 Jan, 2024
Lack of Vitamin D due to lack of Sun, global perspective - Grant Jan 2024 10 Jan, 2024
Vitamin D testing and supplementation would improve health – Grant Jan 2020 05 Oct, 2023
Increasing the vitamin D level of all Canadians to 40 ng would save 6 to 18 billion dollars a year – Grant Nov 2016 23 Aug, 2023
Periodontal Disease and Vitamin D - interview and transcript - GRH, Grant July 2023 02 Aug, 2023
Dental problems if low Vitamin D (Hill's, Global Rec.) - Grant June 2023 02 Aug, 2023
Yes, Vitamin D can be a magic bullet - Grant March 2020 01 Aug, 2023
Reduce 4 health problems by a quarter if increase Vitamin D to 30 ng – Saudi Arabia, Grant March 2023 17 May, 2023
The Role of Vitamin D in Reducing Risk of Alzheimer’s and Dementia - transcript Dr. Grant March 2023 12 Mar, 2023
My Life as a Vitamin D Researcher – Dr. Grant Feb 2023 19 Feb, 2023
The Real Story on Vitamin D: interview and transcript – Grant Dec 2022 10 Dec, 2022
African American Health Disparities are associated with low Vitamin D - Grant Feb 2021 10 Dec, 2022
Vitamin D should reduce hospital-acquired infections – Grant Dec 2012 10 Dec, 2022
Mortality reduced by 35 percent if everyone had 50 ng of vitamin D - Grant Oct 2021 09 Dec, 2022
Interview with transcript concerning UVA, UVB, and health – Grant Dec 2012 09 Dec, 2022
Dr. Grant on vitamin D and mortality in VitaminDWiki 09 Oct, 2022
Mortality reduced if Vitamin D levels raised to 30 ng ( Middle East this time) - Grant Oct 2022 09 Oct, 2022
Debunking Misinformation About Vitamin D - Grant podcast and transcript - Sept 2022 21 Sep, 2022
The problems with healthcare in the U.S., following the disinformation playbook – Grant Dec 2017 23 Jun, 2022
Interview with transcript of Dr. Grant on Vitamin D and Cancer by Dr. Moss - June 2022 23 Jun, 2022
By Dr. Grant in VitaminDWiki 01 Mar, 2022
Vitamin D benefits ignored at a time they are most needed - Grant Jan 9, 2022 10 Jan, 2022
Top Vitamin D Papers - Grant 2017 09 Jan, 2022
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 15 Oct, 2021
Vitamin D and Health video with transcript - Dr. Grant Sept 2021 11 Sep, 2021
Vitamin D and COVID-19: Video and PDF by Dr. Grant (includes recommendations)- Nov 25, 2020 26 Nov, 2020
Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020 02 Apr, 2020
Breast, Prostate and Colon Cancers are still strongly associated with low Vitamin D – Grant Jan 2020 01 Jan, 2020
Evidence that Vitamin D prevents Cancer – Grant Feb 2018 29 Jan, 2018
Vitamin D Video 53 minutes with text and PDFs – Grant Oct 2017 28 Nov, 2017
Canadian grant funding lost for prescribing 50,000 IU of vitamin D – July 2017 23 Jul, 2017
Pregnancy and Vitamin D bibliography - Dr. Grant - March 2017 20 Mar, 2017
Bibliography of Black-White health disparities linked to vitamin D - Dr. Grant March 2017 20 Mar, 2017
Prenancy and Vitamin D biliogrraphy - Dr. Grant - March 2017 20 Mar, 2017
Patent granted for adding vitamin D to sunblock and skin cream - Feb 2011 05 Jan, 2017
Optimum Vitamin D level: Evidence for 30 and 40 ng – Grant Aug 2013 28 Feb, 2016
Low UVB (thus low Vitamin D) is linked to many diseases – Grant Jan 2016 10 Jan, 2016
Time-release form of active vitamin D granted a patent for chronic kidney disease – July 2014 26 Jul, 2015
Vitamin D2 patent granted to prevent hair loss during chemotherapy – 2002 11 May, 2015
Less sun means more disease -Grant, Holick, Cannell, et al Feb 2015 05 Mar, 2015
Autism and vitamin D: Cannell, Grant – March 2013 05 Jan, 2015
Evidence that the minimum vitamin D blood level is 30 ng – Grant Nov 2012 21 Jan, 2014
Summary of Vitamin D trials - Grant Nov 2012 18 Jan, 2014
Solar UVB reduces Cancer Risk – Grant, Jan 2013 02 Oct, 2013
UK Day-Cares being offered grants to develop vitamin D methods – July 2012 27 Dec, 2012
Getting sunshine improves your health provided you do not sunburn - Grant Dec 2012 11 Dec, 2012
Review of Vitamin D trials - Grant Jan 2012 25 Nov, 2012
Abu Dhabi 2012 - Grant 11 Apr, 2012
Evidence for Vitamin D - Grant Aug 2011 09 Nov, 2011
Some cancer due to low UV – Grant – April 2010 13 Oct, 2011
Recommend 2500-4000 IU per day to reduce all-cause mortality by 18%– Grant Netherlands April 2010 13 Jul, 2011
Vitamin D overview by Grant - Jan 2011 13 Jul, 2011

VitaminDwiki - Vitamin D is still NOT Snake oil - Sept 2015



Yes, Vitamin D can be a magic bullet - Grant March 2020        
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